It's virus season — the wanderlust virus, that is. If you're dreaming about warm beaches or experiencing other cultures, we have the perfect cure: book yourself a trip. Avoid lengthy layovers (and opportunities for lost luggage) with one of these nonstop flights from Portland International Airport.

Frankfurt (FRA) | Condor

With one-way fares sometimes dropping below $300, this is perhaps the most budget-friendly way to reach Europe. From Frankfurt, you can take a train, bus, or hopper plane to reach other nearby countries on your bucket list — but while you’re there, check out the Goethe House and Römerberg, a city square with picturesque medieval buildings.

Toronto (YYZ) | Air Canada

The capital of the province of Ontario is the most populous city in Canada — and its financial hub. From the historic Distillery District to CN Tower, there are plenty of things to do to keep metropolis explorers busy. We found roundtrip flights in February for around $360.

Guadalajara (GDL) | Volaris

Picture yourself lounging in a plaza, sipping a margarita (made with tequila from the nearby town where the spirit gets its name), and listening to mariachi — which originated in Guadalajara. Flight prices vary wildly based on your travel dates, but a one-way ticket to Portland’s sister city can be as low as $99.

Maui Kahului (OGG) | Hawaiian Airlines

Hike up a dormant volcano for out-of-this-world views (literally), swim with sea turtles, surf the North Shore, stroll through towering bamboo forests, or drive the Road to Hana — there’s no shortage of island fun in Maui. Roundtrip flights during the off-season can be found in the mid-$300 range.

Albuquerque (ABQ) | Alaska Airlines

If the high desert is calling your name, hop on a nonstop flight from PDX to New Mexico’s largest city — roundtrip flights in February are as low as ~$288. Take a hot air balloon ride over the city, play a round of golf, kayak the Rio Grande, or ride an aerial tram to the 10,378-ft peak of the Sandia Mountains. Pro tip: stay for one of the best sunsets you’ll ever see.

Orlando (MCO) | Alaska Airlines

Visit the land of Disney World, nature encounters with manatees and alligators, and plenty o' sunshine. If you're willing to fly a red-eye, you can find fares below $200.

Austin (AUS) | Alaska Airlines

Buckle up and say "yeehaw" on your ride to the Lone Star State's capital city, where everything from the barbecue to the bats is bigger, but tickets are relatively low from $189 to $300. Say hi to our friends over at ATXtoday while you're there.