As pharma ads stall, newsletters are the new prime time

The ad world is changing, but those with loyal audiences and direct access are already ahead of the curve.

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Graphic by 6AM City

There’s been a major move out of Washington that could upend one of the most powerful forces in modern advertising. Whether you work in media or marketing, it’s the kind of shift that reveals who’s prepared for disruption… and who’s not.

Spoiler: If you have a high-trust, high-engagement newsletter audience, you’re already ahead.

Let’s break it down.

The backstory

Recently President Trump signed a memo that targets direct-to-consumer drug advertising, which could trigger a near-ban on the fast-paced, side-effect-skimming pharma ads we’ve all seen during commercial breaks.

This would reverse a 1997 FDA rule that allowed pharma companies to list some side effects in ads, not all, so long as they linked to the full info elsewhere. That legal loophole is what made those 30-second ads feasible.

Without it? Expect longer (read: more expensive) commercials, or none at all.

Why this is massive

Pharmaceutical brands spent $10.8 billion on ads in 2024. Of that, nearly $5 billion went to national TV, per eMarketer.

  • Pharma made up 24% of all TV news ad slots in the first half of 2025.
  • That generated $2.7 billion in revenue for networks like CBS, ABC, and FOX.
  • Digital and social ad buys are also fueled by pharma’s deep pockets.

If that budget vanishes, even partially, media platforms built on traditional ad revenue will feel the shock.

When ad dollars shrink, trust grows in value

What is the big idea? Attention is fragile. Trust is resilient.

That’s why we believe a local, direct-to-inbox relationship with readers is the most valuable media asset in today’s landscape.

Unlike programmatic TV or social ad buys, newsletters offer:

  • Opted-in audiences
  • Consistent open rates
  • High content engagement
  • Trackable ROI for advertisers

And, most importantly: zero reliance on loopholes or intermediaries.

Here’s your next move

If you’re an advertiser, marketer, or agency rethinking your Q4 strategy, here’s the question to ask: What happens when your biggest channels suddenly become uncertain?

TV can lose pharma. Social can lose targeting. But a well-read, trusted newsletter with local relevance and audience loyalty? That doesn’t fade when regulations change.

It’s built to last.

How 6AM City saw this coming

We’ve built our model around a single, powerful idea: The inbox is the most valuable real estate in media. With 2M+ subscribers across 400+ cities and an average open rate of 41%, we deliver scalable, hyper-local content with national reach, without relying on fragile ad systems.

We don’t rent attention. We own the relationship.

Big picture takeaways

  • A potential pharma ad crackdown could pull billions out of TV and digital.
  • Platforms relying on ad dollars will feel the squeeze.
  • Newsletters with loyal audiences are immune to this volatility.
  • 6AM City’s model is already built for the next era of media.

If you’re rethinking your media buys, start with the inbox. Want to advertise with us? Let’s talk. Want to learn how our model works? We’ll show you the ropes. Because when the platforms shift, local newsletters stay standing.